Personalized anticancer therapy selection using molecular landscape topology and thermodynamics
نویسندگان
چکیده
منابع مشابه
Personalized anticancer therapy selection using molecular landscape topology and thermodynamics
Personalized anticancer therapy requires continuous consolidation of emerging bioinformatics data into meaningful and accurate information streams. The use of novel mathematical and physical approaches, namely topology and thermodynamics can enable merging differing data types for improved accuracy in selecting therapeutic targets. We describe a method that uses chemical thermodynamics and two ...
متن کاملThe Molecular Aspects of Personalized Anticancer Treatment
Only 25% of cancer patients, on average, benefit from therapy. Even in the cases of complete clinical response the tumor progression is an event of high level expectation. The main reasons for tumor progression are: intratumor heterogeneity resulted from clonal evolution, drug resistance, and tumor-promoting microenvironment. The reprogramming of microenvironmental stromal-inflammatory componen...
متن کاملPersonalized Dosimetry for Radionuclide Therapy Using Molecular Imaging Tools
For treatment of systemic malignancies, when external radiation therapy is not applicable, radionuclide therapy can be an alternative. In this form of therapy, radionuclides are administered to the patient, often in a form where the radionuclide is labelled to a molecule that plays the active part in the localization of the tumor. Since the aim is to impart lethal damage to tumor cells while ma...
متن کاملMolecular predictors in glioblastoma: toward personalized therapy.
Recent therapeutic advances have improved standard treatment for patients with newly diagnosed glioblastoma. Unfortunately, even with these improvements, only a fraction of patients derive significant benefit and experience prolonged survival. These findings are consistent with long-standing clinical and recent molecular evidence that subtypes of glioblastoma exist with differing survival rates...
متن کاملPersonalized medicine-molecular targeted cancer therapy
chemotherapy. Metastatic or advanced cancers with limited effects of radiation and chemotherapy have been the challenging issue in recent cancer therapy. In this situation, the molecular target cancer therapy has been successfully accepted for various cancers. This type of therapy is to suppress the cell proliferation or induce apoptosis of cancer cells by targeting particular molecules which p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.12932